Topical Treatments for Erectile Dysfunction
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Injection ED treatments and topical cream treatments for
erectile dysfunction employ various agents that have properties
that help achieve erection. The standard agents used to treat
ED and erectile dysfunction include Alprostadil, Phentolamine
and Papaverine.

An erectile dysfunction study examined a progressive injection
protocol that starts with a less complex and expensive
combination of treatment ED drugs and also advanced to more
complex and costly regimens until positive results are achieved.
The erectile dysfunction ED treatment drugs used in the studies
protocol were papaverine, phentolamine, prostaglandin E1 and
atropine sulfate. The logic behind the protocol is to find the least
costly and complex therapy that works for the patient. Positive
response rates were as high as 97.6%. Although any or all of
these agents are very effective, injections or other invasive
methods of administration are awkward and uncomfortable.
Topical forms of some of these agents are showing promise.

Topical Treatments for ED

Alprostadil is derived from a natural substance, prostaglandin
E1, and acts by opening blood vessels. It is an effective
alternative erectile dysfunction treatment for some men. It can
be administered in three ways. The first is by injection it into the
erectile tissue of the penis. The second is by a device that
administers the ED drug through the urethra. And lastly by using
a topical cream such as Topiglan or Alprox-TD. These topical
ED treatments for erectile dysfunction are an easier and
effective source of treatment.

Regardless of how it is administered, Alprostadil works in many
men with a wide range of medical disorders related to erectile
dysfunctions. These other medical disorders including the
following: diabetes, surgery and physical Injury. In spite of its
general success, self-injection therapy has a high dropout rate
and is less likely to be used now that oral treatments are
available. The drug should not be injected more than three times
a week or more than once within a 24 hour period.

Side Effects of Most Alprostadil ED Methods

Alprostadil is not an appropriate choice for men with severe
circulatory or nerve damage, men with bleeding abnormalities,
men with penile implants or men who are taking medications
that thin the blood, such as heparin or warfarin.

Certain side effects are common to all methods of
administration, although they may differ in severity depending on
how the ED treatment drug is administered. In one study, half of
the men with injected Alprostadil experienced some burning and
pain at the injection site. Side effects with injections may include
scarring of the penis. Other symptoms may include dizziness,
light-headedness, and fainting due to a sudden drop in blood
pressure. If these symptoms occur, the man should lie down
immediately with his legs raised.  As a possibility with any
method, but less chance with the MUSE system than with
injections, a prolonged erection may happen known as
priapism. If this occurs, applying ice for ten-minute periods to
the inner thigh may help reduce blood flow. Erections that last
for four hours or longer requires emergency care.

There is also a possibility of side effects on female partners.
Women partners may experience vaginal burning or itching. The
drug may have toxic effects if it reaches the fetus in pregnant
women, so men should not use Alprostadil for intercourse with
pregnant women without the use of a condom or other barrier
contraceptive device.

Injected Alprostadil such as Caverject or Edex employs a very
small needle that is injected into the erectile tissue of the penis.
About 80% of men report the pain of administering the injection
as being very mild. Edex which is a newer and less expensive
form of injected Alprostadil. In one study of 894 patients, Edex
injections achieved erections in 95% of attempts after 12
months. There is some evidence that the agent may have long-
term benefits on smooth muscles and some men report some
return to spontaneous erections after long-term use.

Topical Treatments for Erectile Dysfunction

Alprostadil is being developed as a topical ED cream or gel as
additional treatment options for erectile dysfunction. These
topical treatment creams include the names Topiglan and
Alprox-TD. The topical ED treatment cream for erectile
dysfunction is applied to the tip of penis 15 minutes before
intercourse. Studies are reporting an efficacy rate of 40% to
75% with no significant side effects. The most common side
effect reported is a burning sensation at the application site.
The consequences to the female partner are not known and
haven’t been studied as of yet.

The ED topical treatment cream for erectile dysfunction acts
locally on penile tissue. If the topical application of cream
precedes sexual intercourse, the release of neurotransmitters
prompted by erotic stimulation will enhance further the action of
the agents and result in a better erection. The greatest effect
was seen in psychogenic erectile dysfunction with or without a
neurogenic disorder and the lowest in vascular erectile
dysfunction. This may be because the agents in the active
topical treatment cream are primarily vasodilators and penile
vasculature is healthy in psychogenic erectile dysfunction but
compromised in vascular dysfunction. During laboratory testing
the active topical treatment ED cream significantly increased
penile arterial flow and induced tumescence in 66% of patients.
Even though more studies are needed, topical treatments for
erectile dysfunction with a cream containing aminophylline,
isosorbide dinitrate, and co-dergocrine mesylate might be
considered before the intracavernous injection of drugs.

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Topical Treatments for Erectile Dysfunction
Injection therapies and topical treatments for erectile dysfunction employ various
agents that have properties that help achieve erection.

Medications that Cause Erectile Dysfunction
Medications used to treat other various medical disorders may cause erectile
dysfunction. If you think erectile dysfunction is caused by a medication, talk with ..
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