Gene Therapy and Erectile Dysfunction

Gene Therapy and Erectile Dysfunction (ED)

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According to a recent study conducted by the Pittsburgh School
of Medicine, rats with (ED) erectile dysfunction that were treated
with a gene therapy containing either of two nerve growth factors
were able to regain normal erectile function after one month.
These incredible findings are being presented at the 10th
annual meeting of the American Society of Gene Therapy at the
Washington State Convention and Trade Center in Seattle. This
extensive study was conducted by Dr. Joseph Glorioso who is
the chair of the department of biochemistry and molecular
genetics, and Dr. Joel Nelson who is the chair of the department
of urology at the University of Pittsburgh School of Medicine.
These two researchers inserted either the gene for the glial cell
line derived neurotrophic factor also named GDNF or the family
ligand (neurturin) into a genetically engineered herpes simplex
virus. They then injected either of the recombinant viruses into
the damaged cavernous nerve of rats. The important nerve
growth promoter named GDNF has been shown in many other
studies to contribute to the regeneration and survival of penile
nerves. Neurturin is also a nerve growth factor closely related to
GDNF. The placebo or the control mice experiment did receive
the virus but not the GDNF or neurterin genes inserted. After one
month of erectile dysfunction (ED) treatment, rats administered
HSV or GDNF exhibited significant recovery of intracavernous
pressure and systemic arterial pressure as opossed to rats
treated with the control virus with (ED) erectile dysfunction. Rats
that were treated with HSV-neurturin also exhibited significant
recovery compared with the control or untreated mice after one
month of erectile dysfunction (ED) treatment. The studies of
fluorescent proteins also showed that the delivered genes had
been effectively incorporated into the target nerve cells which
improved erectile function. According to Dr. Joseph Glorioso,
HSV delivery of GDNF and/or neurturin presents a potentially
important new approach for the treatment of erectile dysfunction.

Treatment for Erectile Dysfunction
Erectile Dysfunction is the inability to get or keep an erection firm enough for
sexual intercourse. The word "Erectile Dysfunction" may also be used to describe

How is Erectile Dysfunction Diagnosed ?
The medical and sexual histories of a person help define the degree and nature
of Erectile Dysfunction. The person's medical history can disclose diseases that

How is ED Treated ?
Most doctor's agree that treatments for ED proceed from least to most invasive.
The first thing in order is cutting back on any drugs with harmful side effects.

Vacuum Devices, Implants and Surgery to Treat ED ?
By creating a partial vacuum, mechanical vacuum devices cause an erection.
This draws blood into the penis, expanding and engorging it. The vacuum device

Topical Treatments for Erectile Dysfunction
Injection therapies and topical treatments for erectile dysfunction employ various
agents that have properties that help achieve erection.

Medications that Cause Erectile Dysfunction
Medications used to treat other various medical disorders may cause erectile
dysfunction. If you think erectile dysfunction is caused by a medication, talk with ..